Search results for "Microbial genome"

showing 2 items of 2 documents

The power and limitations of genomic surveillance of bacteria.

2019

Microbiology (medical)biologyMolecular epidemiologyKlebsiella pneumoniaeHigh-Throughput Nucleotide SequencingBacterial InfectionsGenomicsmedicine.disease_causebiology.organism_classificationMicrobiologyDNA sequencingNeisseria gonorrhoeaeMicrobiologyAnti-Bacterial AgentsKlebsiella InfectionsGonorrheaKlebsiella pneumoniaeAntibiotic resistanceDrug Resistance Multiple BacterialEpidemiological MonitoringNeisseria gonorrhoeaemedicineHumansMicrobial genomeBacteriaFuture microbiology
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Assembly methods for nanopore-based metagenomic sequencing: a comparative study

2019

ABSTRACTBackgroundMetagenomic sequencing has lead to the recovery of previously unexplored microbial genomes. In this sense, short-reads sequencing platforms often result in highly fragmented metagenomes, thus complicating downstream analyses. Third generation sequencing technologies, such as MinION, could lead to more contiguous assemblies due to their ability to generate long reads. Nevertheless, there is a lack of studies evaluating the suitability of the available assembly tools for this new type of data.FindingsWe benchmarked the ability of different short-reads and long-reads tools to assembly two different commercially available mock communities, and observed remarkable differences i…

NanoporeContigMicrobial GenomesComputer scienceMetagenomicsMinionNanopore sequencingComputational biologyBacterial genome sizeGenomeGene
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